PANK2 and Neurodegeneration: Gene mutations in two of the genes involved in CoA biosynthesis, including mitochondrial pantothenate kinase 2 (PANK2) and CoA synthase (COASY) lead to PKAN (Pantothenate Kinase-Associated Neurodegeneration) and CoPAN (COASY Protein-Associated Neurodegeneration), respectively2.