BCL2L11 and posterior cortical atrophy: Here the novel BCL2L11 pLoF DEL on exon 2 with more than 20 supporting read-pairs and with around 50% reduction in read depth (Supplementary Fig. 7 and Supplementary Table 6) was identified in a single African patient presenting at age 71 years with ISUP GG5 PCa, while the novel pLoF TRA interrupting CTNNA1 with more than 20 supporting read-pairs (Supplementary Fig. 16) in a single European patient presenting at age 59 years with ISUP GG5 PCa.