While PCa patients presenting with pathogenic MLH1 mutations were reported to have significantly higher disease burden for African Americans24, here we found a dbVar known MLH1 pLoF INV with around 11 supporting short read-pairs (Supplementary Fig. 12) in a 64 year old African male presenting with ISUP GG4 at diagnosis. The gene discussed is MLH1; the disease is posterior cortical atrophy.