We observed three ClinVardefined pathogenic or likely pathogenic PP-SVs (SLC3A1, OCA2 and PIGN) and 12 predicted PP-SVs, including seven known SVs (SLC7A2, DNAJC15, COL4A2, SLC2A5, WASF1, MLH1 and RB1), and five novel SVs (BCL2L11, BARD1, FOXP1, CTNNA1 and AK8-DST), suggesting that inherited SVs may constitute an under-appreciated contribution to PCa pathogenicity. This evidence concerns the gene RB1 and posterior cortical atrophy.