Identifying a potentially pathogenic INV previously reported at MAF of 9.6e-05 in Africans and resulting in NR2E1-WASF1 fusion was identified in a single African patient presenting at 70 years of age with ISUP GG5 PCa, showed 14 supporting read-pairs (Supplementary Fig. 14). Here, NR2E1 is linked to posterior cortical atrophy.