TNF and asthma: Notable genes that were differentially methylated based on asthma severity included <i>RUNX3</i>, several members of the <i>HLA</i> family, <i>AGT, PTPRC, PTPRJ,</i> and several genes downstream of the <i>JAK2</i> and <i>TNF</i> signaling pathway.<h4>Conclusion</h4>These findings demonstrate how adults with asthma of varying severity possess differences in peripheral blood T cell DNA methylation that contribute to the phenotype and severity of their overall disease.