IFNA1 and Dravet syndrome: Furthermore, we recently demonstrated that IFN transcriptional scores derived from peripheral immune cells correlate significantly with the degree of immune remodeling and hypercytokinemia in DS44, and we and others have reported the safe use of JAK inhibitors for treatment of diverse immune conditions in DS, including alopecia areata51, psoriatic arthritis52 and hemophagocytic lymphohistocytosis53 through small case series.