PHF1 and tauopathy: To assess the immunogenicity and efficacy of the Qβ-AT8 and Qβ-PHF1 vaccines, 2-month-old transgenic rTg4510 tauopathy mice were intramuscularly immunized three-times with Qβ-AT8, Qβ-PHF1, or, as a control, unconjugated Qβ VLPs at biweekly intervals (Fig 1b).