TM4SF1 and neoplasm: We now report (i) inhibition of B16F10 tumor growth and wound healing in Tm4sf1‐heterozygous mice, and (ii) that 12 out of 18 signaling molecules examined are recruited to TMED on the cell surface and 10 were found to internalize with TMED; PLCγ and HDAC6 notable among them.