reported a conflicting finding, which demonstrated that IGFBP‐3, DKK‐3, and DKK‐1 produced by amniotic membrane‐derived human amniotic membrane mesenchymal stem cells (hAMSCs) impede HSC activation and alleviate the mouse hepatic fibrosis by blocking the classical Wnt signaling. This evidence concerns the gene DKK3 and Hepatic fibrosis.