Activated HSCs are key to the formation and progression of liver fibrosis and are marked by α‐SMA expression, and the production of a large amount of extracellular matrix (ECM) shows to be dominated by collagen type I (COLLAGEN I, COL1A1), and collagen type III (COLLAGEN III, COL3A1).22 This evidence concerns the gene COL1A1 and Hepatic fibrosis.