reported a conflicting finding, which demonstrated that IGFBP‐3, DKK‐3, and DKK‐1 produced by amniotic membrane‐derived human amniotic membrane mesenchymal stem cells (hAMSCs) impede HSC activation and alleviate the mouse hepatic fibrosis by blocking the classical Wnt signaling. Here, IGFBP3 is linked to Hepatic fibrosis.