Additionally, Wang66 and Song67 reported through Western Blot analysis, PCR assays, and lentivirus transfection experiments that WISP1 promotes HNSCC invasion and metastasis while modulating glycolysis and chemoresistance via YAP1/TEAD1/GLUT1 signaling pathway as well as TGF‐β‐Smad2/3 signaling pathway regulation. Here, CCN4 is linked to head and neck squamous cell carcinoma.