TNC and esophageal squamous cell carcinoma: It was also reported that silencing the expression of TNC down‐regulated the expression of cancer stem cell‐like cell marker SOX2 and EMT‐related marker Snail, while Perifosine, an inhibitor of Akt signal, could inhibit the protein expression of HIFA α and TNC in esophageal squamous cell carcinoma cells.134