SIRT1 and cancer: Strengths of the study include using a well‐established cancer cachexia model to show that there is decreased sirt1 expression in muscles from cachectic mice, modulating sirt1 expression using a safe and FDA approved drug as well as an experimental compound in vitro to prevent the decrease of C2C12 myotube diameter in cachectic conditions, and showing that both NA and SRT1720 attenuate mitochondrial oxidative stress.