NOX4 and intracerebral hemorrhage: Studies have implicated NADPH oxidase 4 (Nox4) as a culprit for increased mitochondrial ROS production in a variety of pathophysiological conditions including cardiovascular disease (Vendrov et al., 2015), intracerebral hemorrhage (Ding et al., 2023), and cancer cachexia (Dasgupta et al., 2020).