Notably, a substantial number of upregulated genes associated with depression were identified, such as Ctss, Ifitm3, H2‐K1, Vim, Bst2, Lag3, Cd74, Isg15, Gbp3, and Cxcl10 (Figure 6B; Table S3, Supporting Information). This evidence concerns the gene IFITM3 and major depressive disorder.