SLC7A5 and neoplasm: LAT1 is often of interest because of its overexpression in tumor cells, which requires large amounts of amino acids.[26, 27] There is also evidence that LAT1 is involved in pain,[35] such as increased LAT1 levels in DRG and spinal cord of spared nerve injury mice.[36] Although some reports have provided evidence that LAT1 inhibits Kv1.2 channel current density,[28, 29, 30] its physiological significance is not fully understood.