SLC7A5 and Hyperglycemia: Of the many behavioral tests available, touch and thermal stimuli most closely reflect the aspects of clinical Quantitative Sensory Testing and do not require animal restraint.[38] The occurrence and extent of DNP may vary depending on the mouse model, mouse strain, mouse age, and the severity of insulin deficiency and/or hyperglycemia.[38] In the HFD/STZ mouse model, some with symptoms of DNP and others without, this study found that upregulation of LAT1 expression is one of the reasons.