In high‐fat diet/low‐dose streptozotocin (HFD/STZ)‐induced T2DM and leptin receptor‐deficient diabetic (db/db) mouse models, we found that BCAA deficiency in the mouse dorsal root ganglion (DRG) led to compensatory upregulation of LAT1 levels. This evidence concerns the gene SLC7A5 and type 2 diabetes mellitus.