Even in the presence of high concentrations of C-X-C motif chemokine ligand 10 (CXCL10) or C-X-C motif chemokine ligand 4 (CXCL4), a T-cell chemoattractant, the infiltration of T cells in the TME is blocked due to the hypercrosslinked collagens and dense glycoproteins surrounding the tumor cells[89]. Here, PF4 is linked to neoplasm.