Our laboratory demonstrated that O-GlcNAc modified hepatocyte growth factor-regulated tyrosine kinase substrate (HGS), a key component of the endosomal sorting machinery, and subsequently repressed its interaction with intracellular PD-L1, resulting in impaired lysosomal degradation of PD-L1 and promoting tumor immune evasion[74]. Here, CD274 is linked to neoplasm.