FUT8 catalyzes core fucosylation at N-linked glycans, contributing to membrane B7H3 expression and immunosuppression in triple-negative breast cancer(TNBC).FUT8 knockdown promotes T-cell proliferation and activation, and combined treatment with a 2-fluoro-L-fucose (2F-Fuc) inhibitor and an anti-PD-L1 antibody improves the efficacy of anti-PD-L1 immunotherapy[80]. The gene discussed is CD274; the disease is triple-negative breast carcinoma.