Under most circumstances, 5‐HT‐induced vasoconstriction is mediated primarily through 5‐HT2A but mediation could also occur through 5‐HT1B, 5‐HT1D, or 5‐HT2B during hypertension (Banes & Watts, 2002; Klotz et al., 2018; Russell et al., 2002). The gene discussed is HTR2B; the disease is Hypertension.