CD274 and cancer: In addition, we searched for genomic alterations in the EREG-EGFR-PDL1 pathway from the TCGA data via the cBio Cancer Genomics Portal as previously described.11 OncoPrint analysis showed that alterations in genes from the EREG-EGFR-CD274 pathway were mutually exclusive (Supplementary Fig. 2c), suggesting that overexpression of these genes has a similar functional role.