The landscape of the relationship between EREG expression and 28 types of tumor-infiltrating lymphocytes in different types of cancer showed that EREG expression was negatively correlated with the infiltrated Act CD8 (r = −0.115, P = 0.008 68) and Act CD4 (r = −0.203, P < 0.01) cells in HNSCC (Supplementary Fig. 1a, b), and positively correlated with infiltrated neutrophils cells (r = 0.567, P < 0.01) and monocytes (r = 0.186, P < 0.01) in HNSCC (Supplementary Fig. 1a, b). This evidence concerns the gene CD4 and head and neck squamous cell carcinoma.