Then, we generated mice with conditional overexpression of YAP1 in AT2 cells (YAP1-cKI mice) by crossing YAP1S127A (a vector containing a YAP1 DNA sequence without a phosphorylation site via the S127A mutation) mice with Sftpc-Cre mice to explore whether the forced expression of YAP1 in AT2 cells can inhibit experimental pulmonary fibrosis (Fig. 3a, b). This evidence concerns the gene SFTPC and pulmonary fibrosis.