However, a previous study revealed aberrant activation of the Hippo/YAP signaling pathway in AT2 cells of IPF patients26, and Alexander et al. showed that increased expression of YAP in epithelial progenitor cells of the embryonic lung resulted in pulmonary lesions, a characteristic shared with IPF27; these findings were contradictory to our results. The gene discussed is YAP1; the disease is idiopathic pulmonary fibrosis.