One of the prevalent factors in heart failure is dilated cardiomyopathy (left ventricular dilatation with contractile dysfunction), which involves pyroptosis in cardiomyocytes via the integrated induction of NADPH oxidase (NOX1 and NOX4) and dynamin-related protein 1 (Drp1) via activation of the NLRP3 inflammasome86. The gene discussed is DNM1L; the disease is heart failure.