RegIIIγ, the mouse homolog of human REG3A (also known as the human hepatocarcinoma-intestine pancreas or human pancreatitis-associated protein), has been found to attenuate the diabetic phenotype during STZ-induced islet damage and obesity-induced islet abnormalities by modulating pancreatic immunity and promoting pancreatic β cell regeneration61,62. Here, REG3A is linked to obesity due to melanocortin 4 receptor deficiency.