To investigate whether intracellular delivery of either NO2Hsp90, Hsp90NY33, or Hsp90NY56 into normal Schwann cells, which do not contain detectable levels of endogenously nitrated Hsp90 [27], recapitulated the enhanced proliferative phenotype observed in schwannoma cells, we delivered these recombinant proteins into Schwann cells at levels comparable to those endogenously found in VS from NF2-SWN patients and schwannoma cells (Fig. 1), and determined cell growth 24 and 48 h post-delivery (Fig. 3A). The gene discussed is NF2; the disease is schwannoma.