While intracellular delivery of Hsp90NY276 had no apparent proliferative effect (Fig. 2A), similar to the effect observed for NO2Hsp90, nitration of either Y33 or Y56 in Hsp90 was sufficient to induce a proliferative gain-of-function in schwannoma cells 24 h post-delivery (Fig. 2A). Here, HSP90AB1 is linked to schwannoma.