When DSS + IFX (ie, colitis + infliximab) groups of different strains were compared, 14 metabolic pathways were enriched in octn1-/- mice, including amino acid, carbohydrate, thiamine, sphingolipid, cyano-amino acid metabolism, glycan and phenylpropanoid biosynthesis, and 2 of photosynthesis. Here, SLC22A4 is linked to colitis.