SLC22A4 and colitis: To evaluate the impact of OCTN1 on intestinal microbiota and its colitis-associated modifications, we took advantage of a KO mouse strain originally generated by Kato et al.9Octn1-/- mice displayed a milder disease compared with WT after induction of colitis with DSS, with a lower DAI score for the entire duration of the treatment and less severe mucosal damage and inflammatory infiltration at sacrifice.