CUX1 and atherosclerosis: Based on post-genome-wide association studies (GWAS) functional studies on the aging-related CDKN2A/B locus [12], we recently demonstrated that CUX1 is an activator of p16INK4a, regulating p16INK4a-dependent cellular senescence via its binding to an atherosclerosis-associated functional SNP (fSNP) rs1537371 on the CDKN2A/B locus [13].