As we did not observe any nearby (1 Mb upstream or downstream) common variants in ATP2C2 associated with cross-sectional COPD (all p > 5 × 10−6), the association between bi-allelic variants of ATP2C2 and COPD potentially is driven by the unique configurations of CH damaging missense (n = 7) and pLoF (n = 1) variants that primarily reside in functional protein domains (Figures 5E and S24; Table S21). The gene discussed is ATP2C2; the disease is chronic obstructive pulmonary disease.