ATP2C2 and chronic obstructive pulmonary disease: Compared to individuals with a single disrupted haplotype, both homozygous and CH carriers of pLoF + damaging missense/protein-altering variants in ATP2C2 were at an increased lifetime risk of developing COPD (homozygote hazard ratio [HR] = 6.65 [95% CI = 4.5–8.8], p = 0.084, CH HR = 8.98 [95% CI = 7.79–10.17]; p = 0.00028).