BRCA1 and ovarian carcinoma: Data from The Cancer Genome Atlas (TCGA) revealed that RAD18 mRNA is more highly expressed in BRCA1-mutated breast tumors (73,74), relative to BRCA2-mutated and WT tumors (Figure 6A, left), although RAD18 mRNA expression does not appear to be significantly enriched in BRCA1-mutated ovarian carcinomas (Figure 6A, right).