Strategies such as TGF‐β signalling blockade, knockdown of hepatoma‐intrinsic Mettl1 or Tgfb2, or interruption of the METTL1‐TGF‐β2‐PMN‐MDSC axis can mitigate tumour progression induced by iRFA and restore the CD8+ T cell population.141. This evidence concerns the gene TGFB2 and hepatocellular carcinoma.