The METTL1/WDR4‐mediated m7G modification in tRNA plays a pivotal role in various digestive system neoplasms, including HCC, oesophageal squamous cell carcinoma (ESCC), gastric cancer (GC), intrahepatic cholangiocarcinoma (ICC). This evidence concerns the gene METTL1 and intrahepatic cholangiocarcinoma.