Quantification on the distribution of ANC@RNP in various organs showed that brain tumor accumulation of ANC@RNP increased to 6.1% of injected dose per gram of tissue (% ID/g), which was 2.7‐ and 7.3‐fold higher than treatment with NC@RNP or free RNP control, respectively (Figure 3f). The gene discussed is RNPC3; the disease is brain neoplasm.