To facilitate BBB penetration, we grafted Apolipoprotein E (ApoE) peptide onto the surface of our nanocapsules, which further expedites BBB transcytosis and tumor targeting of Cas12a RNP.[22] The ApoE‐decorated nanocapsules were fabricated via in situ polymerization, with encapsulation of Cas12a/crRNA RNP yielding the final nanosystem ANC@RNP.[21] The physicochemical properties of ANC@RNP, such as complexation ability, particle size, and zeta potential, were assessed by dynamic light scattering (DLS) and transmission electronic microscopy (TEM). Here, RNPC3 is linked to neoplasm.