Recently published work indicated that small nanocapsules efficiently transported Cas9/gRNA in vitro and in vivo.[21] Given that Cas9/gRNA and Cas12a/crRNA RNP share similar characteristics, we expanded the nanocapsules delivery strategy for Cas12a/crEGFR‐PLK1 RNP system and evaluated its potential in GBM suppression. Here, PLK1 is linked to glioblastoma.