In several human malignancies, such as renal cell carcinoma, colon and lung adenocarcinomas, and ovarian cancer, where they have been demonstrated to facilitate metastasis, STs may accumulate up as a result of increased galactosylceramide sulfotransferase (Gal3ST1) increased activity [38]. Here, GAL3ST1 is linked to hereditary clear cell renal cell carcinoma.