Relative plasma NDEV levels were measured in a subpopulation of CN participants (n = 62, mean age of 64.9 [7.02], mean MMSE of 28.7 [1.15], 32 women [60.4%], APOE ε4 carriers/ε4 non-carriers [27/35]) and AD patients (n = 54, mean age of 70.1 [8.82], mean MMSE of 24.2 [4.3], 30 women [54.5]). This evidence concerns the gene APOE and Alzheimer disease.