Lipotoxic stress enhances the expression of VCAM-1 in LSECs through MLK3/P38 signaling, while inhibition of VCAM-1 can inhibit adhesion and transendothelial migration of monocytes across LSECs (from wild-type mice fed a high-fat diet and from ob/ob obese mice) and improves liver inflammation [31, 124]. The gene discussed is VCAM1; the disease is Hepatitis.