The LSECs endotheliopathy during MASH is characterized by progressive overexpression of adhesion molecules, including intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1 (VCAM-1) and vascular adhesion protein 1, as observed in the MASH mouse model [119–124]. The gene discussed is VCAM1; the disease is metabolic dysfunction-associated steatohepatitis.