MYC and Hepatic fibrosis: The genetic defect of Gata4 in adult mouse LSECs leads to continuous endothelial dedifferentiation and peri-sinusoidal liver fibrosis, which involves downregulation of BMP-2 and Wnt-2 signaling, activation of transcription factor MYC, and de novo expression of hepatic stellate cell activating cytokine platelet-derived growth factor (PDGF) subunit B. This suggests that endothelial GATA4 prevents perisinusoidal liver fibrosis by inhibiting MYC activation and fibrogenic vascular secretion signal transduction at the chromatin level [33, 47].