Some genes (MYO6, MYH9, ERCC6) were identified in nearly every relevant phenotype and/or pathway, while others (OTOGL, TRIOBP, COL11A2, COL4A3), have well established connections to hearing disorders in the literature[24–27], yet they were not the most recurrently mutated genes, with 12 or fewer samples having a qualifying variant. The gene discussed is COL4A3; the disease is hearing disorder.