In this study we determined the frequencies of CD4 + and CD8 + Tregs in a HAM/TSP population, compared to asymptomatic carriers and uninfected individuals, as well as investigated the profiles of regulatory and inflammatory cytokines.<h4>Methods</h4>Asymptomatic HTLV-1 carriers and HAM/TSP patients were matched by sex and age. Here, CD4 is linked to tropical spastic paraparesis.