Amplification of the MYC transcription factor family member MYCN drives a range of solid tumours including medulloblastoma, rhabdomyosarcoma, osteosarcoma, Wilms tumour, small cell lung cancer and retinoblastoma, with MYCN overexpression associated with poorer prognoses (Rickman Schulte and Eilers, 2018). The gene discussed is MYC; the disease is retinoblastoma.