BCR and chronic myelogenous leukemia, BCR-ABL1 positive: BCR-ABL fusion tyrosine kinase (FTK) has long been linked to HRR activation and the emergence of therapy resistance in Chronic Myelogenous Leukaemia (CML); a scenario similar to MM (Salles et al, 2011; Slupianek et al, 2005; Slupianek et al, 2002; Slupianek et al, 2006; Slupianek et al, 2001).