One area of CYPA biology that has attracted a lot of recent attention concerns its relationship with LLPS (liquid-liquid phase separation) of IDPs (intrinsically disordered proteins), particularly regulating IPDs such as α-synuclein and TDP-43, which are implicated in the neurodegenerative sequalae of disorders such as Amyotrophic Lateral Sclerosis (Babu et al, 2021; Babu et al, 2022; Favretto et al, 2020a; Favretto et al, 2020b; Lauranzano et al, 2015; Pasetto et al, 2021; Pasetto et al, 2017). This evidence concerns the gene PPIA and amyotrophic lateral sclerosis.