MYCN and neuroblastoma: Approximately 25% of paediatric neuroblastoma (NBm) is associated with robust MYCN amplification (often ≥100× copies), exhibiting elevated replication stress (RS)-mediated genomic instability, and characterised by a more aggressive and poorly responding form of the disease (Carén et al, 2010; Maris 2010; Pugh et al, 2013).