Of note, we found 102 apoptosis-related proteins deregulated in t(11;14) myeloma, including downregulation of apoptosis inhibitor BIRC2 and BCL2L1 (BCL-XL) and upregulation of proapoptotic proteins such as TRADD and FADD (Fig. 2a and Extended Data Fig. 3a,b). This evidence concerns the gene BIRC2 and plasma cell myeloma.