Several proteins involved in proteasomal degradation, proteostasis and protein folding pathways were upregulated in MM with 1q gain/amplification including proteins regulated in cis such as the E2 ligase UBE2Q1 (Fig. 3c) and the E3 ligase DCAF8 as well as in trans such as members of the chaperonin containing TCP-1 complex and E2 ligases UBE2G2 and UBE2H (Extended Data Fig. 6d). Here, DCAF8 is linked to Miyoshi myopathy.