Further studies involving not just the Sillence types resulting from pathogenic genomic variants in COL1A1 and COL1A2 but also patients with OI type 5 and 6 and many of the OI numerical types characterized by variants in genes coding for enzymes involved in post-translational modifications of type I collagen proteins (such as SERPINF1, CRTAP, P3H1, SERPINH1, FKBP10), have been found where the application of BEI to thin sections of biopsied iliac crest is characterized by hypermineralization of bone tissue [19]. Here, COL1A1 is linked to osteogenesis imperfecta.