LRP5 and osteoporosis: The heterozygous WNT1 variants result in Familial Osteoporosis except that, as further patients are reported with pathologic genomic variant in LRP5 plus a synergistic variant in a second locus such as WNT1, DKK1, WNT3A, SFRP4, the pathogenesis of the familial osteoporosis spectrum of disorders is widened [82].