Scleral biopsies in life may be risky but the existence of mutant zebra fish carrying genomic variants equivalent to OI type 1, i.e. mutants with nonsense, frameshift or splicing sequence variants in col1a1a, col1a1b or col1a2, could assist to resolve the question about the nature of this matrix component which accumulates in OI type 1 [29]. Here, COL1A2 is linked to osteogenesis imperfecta type 1.