TXN and contact dermatitis: Other models where TRX-1 showed its therapeutic impact was in a mouse model of irritant contact dermatitis induced by croton oil.18 Topically applied recombinant human TRX-1 suppressed the local inflammatory response evidenced by a reduction of cytokines and chemokines, such as TNF-α, IL-1β, IL-6, CXCL1, and MCP-1 in the dermal tissue.