An inverse correlation was noted with forced pulmonary expiratory volume.19 Serum levels of TRX-1 were increased in patients with sepsis compared to healthy individuals, and it was noted that non-survivors showed even higher TRX-1 levels compared to survivors.20 TRX-1 levels have been found elevated in patients with acute lung injury both in the bronchoalveolar lavage and serum.21 Sections of lung tissue showed greater expression of thioredoxin in alveolar macrophages and type II epithelial cells. This evidence concerns the gene TXN and injury.