SNORD118 and acute myeloid leukemia: Moreover, in a mouse model that carries the two most prevalent gene mutations in AML, Npm1c and Flt3-ITD [25], we observed an upregulation of SNORD118 expression as well as the expression of Rnu3b family members (mouse orthologs of human SNORD3A) upon leukemia induction by double mutations (DM) (Fig. 4D).