Cross validation using inducible lentiviral shRNA guided knockdown of SNORD118 also confirmed its essential role in sustaining cell growth and repopulating capacity in MV4-11 cells as well as in two additional AML cell lines, OCI-AML3 and MOLM-13 cells (Supplementary Fig. 5A–I). Here, RUNX2 is linked to acute myeloid leukemia.