Cross validation using inducible lentiviral shRNA guided knockdown of SNORD118 also confirmed its essential role in sustaining cell growth and repopulating capacity in MV4-11 cells as well as in two additional AML cell lines, OCI-AML3 and MOLM-13 cells (Supplementary Fig. 5A–I). This evidence concerns the gene SNORD118 and acute myeloid leukemia.