Moreover, in a mouse model that carries the two most prevalent gene mutations in AML, Npm1c and Flt3-ITD [25], we observed an upregulation of SNORD118 expression as well as the expression of Rnu3b family members (mouse orthologs of human SNORD3A) upon leukemia induction by double mutations (DM) (Fig. 4D). Here, FLT3 is linked to acute myeloid leukemia.