Interestingly, we also reported a significant decrease in HMOX1 expression in 12-months old livers which is consistent with the increased expression of transcription factor Bach1, a master transcription repressor having HMOX1 as one of the main targets [36, 37], reported in the brain of DS subject, and further demonstrated in Ts2Cje mice model by Perluigi’s et al. [34, 36]. Here, BACH1 is linked to Dravet syndrome.