These results are strictly related to the triplication of genes associated with AD such as amyloid precursor protein (APP), β-secretase 2 (BACE2), and S100 calcium binding protein B (S100B) [9], which along with the oxidative unbalance characterizing DS, promote the accumulation of amyloid beta-peptide (Aβ) [3]. Here, APP is linked to Alzheimer disease.