ADIPOQ and obesity due to melanocortin 4 receptor deficiency: Examples of such traits in males compared to females are as follows: higher cardiometabolic risk markers following feeding with high-fat or specific FA-rich diets (81, 82); lower circulating adiponectin, a trait which we confirmed in the present study (data not shown) (83); marked resistance to genetic modification that mitigates obesity or promotes adipose tissue browning (78, 84).