Whilst not in the same class of drugs, vinorelbine is a chemotherapeutic agent that acts by the inhibition of tubulin which is encoded by the same target TUBB3. An RCT comparing vinorelbine combined with gemcitabine vs gemcitabine alone in patients with stage III or IV non-small cell lung cancer demonstrated a higher rate of incident AF.85 The gene discussed is TUBB3; the disease is atrial fibrillation.