Of the druggable targets 31 (ADRB1, ENPEP, EPHA3, FGFR1, HBEGF, HCN4, IL6R, KCNH2, KCNJ5, MAPT, MC4R, MET, MYH6, MYL4, NDUFAF3, NDUFB10, NPR3, PDE3A, PDE4B, PRKCA, PSMB7, PTK2, SCN5A, SRD5A3, THRB, TNSFSF12, TNFSF13, TNNT3, TUBB3, WT1 and XPO1) were also associated with blood pressure and hypertension traits (Supplementary Table S11). The gene discussed is PDE3A; the disease is hypertensive disorder.