Whilst not in the same class of drugs, vinorelbine is a chemotherapeutic agent that acts by the inhibition of tubulin which is encoded by the same target TUBB3. An RCT comparing vinorelbine combined with gemcitabine vs gemcitabine alone in patients with stage III or IV non-small cell lung cancer demonstrated a higher rate of incident AF.85 This evidence concerns the gene TUBB3 and non-small cell lung carcinoma.