While previous studies have reported a reduced centrality in occipital regions among healthy APOE4 carriers (Wink et al., 2018), individuals with mild cognitive impairment (MCI) (Meinzer et al., 2012) and in AD populations (Binnewijzend et al., 2014, Sanz-Arigita et al., 2010, Rombouts et al., 2009), our findings diverge from this pattern. Here, APOE is linked to Alzheimer disease.