In a future study, which should include more subject for each genetic profile, ideally in a longitudinal setting, it would be interesting to see if specific brain connectivity modifications are present in individuals with APOE2, possibly protective for AD (Farrer et al., 1997), and investigate differences from APOE4 related brain patterns regarding implicated brain regions, but also for predictive, individual risk profiling. Here, APOE is linked to Alzheimer disease.