APOE and Alzheimer disease: The presence of Apolipoprotein E4 (APOE4) allele, in contrast to the other two polymorphic alleles E2 and E3, has been shown to accelerate aging effects at the brain level (Deary et al., 2002) and increase the risk of developing AD (Wadhwani et al., 2019, James Bryan and Bennett, 2019, Serrano-Pozo et al., 2021).