APOE and Alzheimer disease: A series of studies have focused on the progression of clinical symptoms and cognitive decline in MCI and AD, suggesting a spectrum with shared neuropathology characterized by impaired resting-state brain network connectivity, with accelerated progression in APOE4 carriers (Sperling et al., 2010, Kanai et al., 1999, Wang et al., 2017, Karcher et al., 2020, Sanabria-Diaz et al., 2021, Sanabria-Diaz et al., 2021).