The main pathophysiology of NAFLD is insulin resistance (IR), and studies have already been conducted on noninvasive biomarkers of IR.[13–16] The triglyceride–glucose (TyG) index has emerged as a reliable surrogate marker for IR.[17,18] Alanine aminotransferase (ALT) is used as a standard indicator of liver function to reflect liver inflammation and damage in patients with various chronic liver diseases, including NAFLD. This evidence concerns the gene GPT and Insulin resistance.