The top 10 proteins calculated from each topological analysis were intersected, resulting in the identification of 5 intersecting proteins that were believed to be the key proteins involved in the pharmacological effects of LXWHT in the treatment of rosacea (Fig. 6), which included chemokine ligand 2 (CCL2), interferon-γ (IFNG), interleukin-1ß (IL1B), peroxisome proliferator-activated receptor-γ (PPARG), and matrix metallopeptidase 9 (MMP9). This evidence concerns the gene MMP9 and rosacea.