TNF and rheumatoid arthritis: For the core targets in the KEGG analysis, enrichment was mainly observed in the TNF and IL-17 signaling pathways, the advanced glycation end products-receptor for advanced glycation end products signaling pathway in diabetic complications, fluid shear stress, and atherosclerosis, Lipid and atherosclerosis, rheumatoid arthritis, malaria, and Toll-like receptor signaling pathways, provided further evidence of the potential anti-inflammatory and immunomodulatory effects of LXWHT.