Moreover, 7 genes were screened out with LASSO to construct the regression model including COL17A1, DEFA1B, BHLHE40, FAM26D, FSTL3, SH3BP5, and SPX, which were found that significantly diversely expressed in different types of placentas, while its function in preeclampsia remained to be investigated. Here, CALHM4 is linked to preeclampsia.