For example, ferritin heavy chain 1 (FTH1), a marker of ferroptosis, was regulated by curcumenol via lncRNA H19/miR-19b-3p/FTH1 pathway.[9] Butyrate promotes ferroptosis of lung cancer cells by regulating ATF3/SLC7A11 pathway.[10] Isoorientin regulated ferroptosis and reversed cisplatin resistance by controlling the Nrf2/GPX4 pathway.[11] Thus, it is crucial to clarify the key genes and molecular mechanisms that regulate ferroptosis in the progression of LUAD. The gene discussed is FTH1; the disease is lung cancer.