It has been reported FKBP3 regulated oxalipalatin resistance via regulating HDAC2 expression in colorectal cancers.[24] It also promoted the NSCLC progression via Sp1/HDAC2/p27.[25] However, the exact role and molecular mechanism of FKBP3 were not clearly clarified in LUAD progression. This evidence concerns the gene HDAC2 and colorectal cancer.