Interacting with growth factor receptor-bound protein 2, this protein is implicated in facilitating TCR-mediated intracellular signal transduction, thereby positively influencing T-cell development and activation, alongside mast cell and platelet functionality.[47,48] Suggesting that the LCP2 gene may play an important role in TCR-mediated intracellular signaling in RA and CD immune responses. Here, GRB2 is linked to rheumatoid arthritis.