ERBB2 and breast cancer: This groundbreaking research was conducted on HER2-positive BC cell lines, namely BT-474 and SKBr-3.[45] The author also discovered that in tumor-derived cell lines SK-Br3, SKOV3, and NCI-N87 (HER2 positive), monounsaturated fatty acid oleic acid-induced the transcriptional repression of HER2 through the action of the Polyomavirus enhancer activator.