GPT and Sepsis: It was first proposed by researchers in 1957 and is often used to assess liver function and indicate the severity of liver disease.[1] Importantly, the AST/ALT ratio has also emerged as a significant indicator of extracellular diseases, predicting the occurrence and prognosis of nasopharyngeal, rectal, prostate, and other tumors.[15–17] Additionally, it can predict the risk of death in patients with sepsis.[18] It is also an effective indicator of cardiovascular diseases.