Common clinical features of PPS include fever and elevated C-reactive protein (CRP) levels without alternative causes, pericardial or pleuritic chest pain, new onset of atrial fibrillation as well as evidence of pericardial and pleural effusions, but clinical presentation is variable and severity ranges from only mild symptoms to severe pleuro-pericardial involvement requiring reintervention (i.e., pleurocentesis or thoracoscopy, pericardiocentesis or pericardiotomy) [3]. The gene discussed is CRP; the disease is Pleural effusion.