Although no statistically significant difference emerged between the T2DM and non-DM groups regarding genotype or allele frequencies, the calculation of OR indicated that the genotypic distributions of the TCF7L2 rs7903146 (TT) and rs4506565 (TT) polymorphisms carried a risk for pre-DM, with an OR (95% CI) of 2.74 (0.32–23.3) and 2.71 (0.32–23.07), respectively. Here, TCF7L2 is linked to diabetes mellitus.