Resistin, IL-6, TNF-α, and CRP were not significantly associated with overweight/obesity in this population.<h4>Conclusion</h4>Adiponectin behaves similarly in Hispanic youth as it does in other pediatric populations, possibly making it a valuable marker when examining metabolic health status in this population. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.