ANO6 and tauopathy: Likewise, when we assessed microgliosis, we found that removal of TMEM16F from neurons reduced levels of microgliosis in tauopathy mice (PS19+ N-Cre+ 16Ffl/fl) compared to those with TMEM16F intact (PS19+ N-Cre− 16Ffl/fl) (Fig. 3 C and D).