In this study, we sought to explore the role of TMEM16F in neurodegeneration in the P301S tau (PS19) mouse model of tauopathy, which expresses mutant human tau with the P301S mutation found in frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17) patients (28). The gene discussed is MAPT; the disease is semantic dementia.