Cleavage between TSR1 and TSR2 by cancer-associated protease matrix metalloproteinase 14 (MMP14) yields an anti-angiogenic N-terminal fragment (Vasculostatin-40; predicted size of 34.7/35.0 kDa for human/mouse) which migrates at ~ 37–40 kDa and a remaining truncated membrane receptor (predicted size of 138.8 kDa), which migrates at ~ 160 kDa. The gene discussed is ADGRB1; the disease is cancer.